Manchester City will look to cut the gap between themselves and Liverpool at the top of the table when they travel to Newcastle United on Saturday.
West Ham will hope to start their climb away from the relegation zone when they travel to Chelsea on Saturday afternoon.
Celtic have been excellent in the Europa League to date and will be looking to seal top spot in Group E when Rennes visit on Thursday.
Group G is one of the most competitive in the Europa League and Rangers' trip to Feyenoord will have a huge say on who qualifies.
Both Braga and Wolves know a point will see them qualify from Europa League Group K and they may play out a cagey game on Thursday.
Manchester United face a long trip east on Thursday to take on Astana in the Europa League.
Arsenal boss Unai Emery is a man under pressure and will hope for some respite when Eintracht Frankfurt visit on Thursday.
Frank Lampard’s says Wednesday’s Champions League trip to Valencia is a “must not lose game” for his Chelsea side.
Liverpool are set to welcome back Mohamed Salah for Wednesday’s Champions League meeting with Napoli at Anfield.
#mcfc could scupper rivals #mufc after offer a deal for Old Trafford defensive target tinyurl.com/nbjycws
#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
Friendly cash bonus for #mcfc tinyurl.com/nwvap9s
No plan for #mufc upgrade that Van Gaal was seeking tinyurl.com/ntqlklz
#burnley make their first signing of the summer with a swoop on #avfc tinyurl.com/nzjolto
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Agent claims #LFC interest in Ligue 1 defender tinyurl.com/q7kbpu7
Sheffield United will look to extend their unbeaten run to six matches when they welcome Manchester United to Bramall Lane.
Watford will be looking win back-to-back games for the first time this season when they host Burnley at Vicarage Road.
Norwich City will hope to climb off the foot of the Premier League table when they face Everton this weekend.
Josh King has been ruled out of Bournemouth's squad to face Wolves, who head to the south coast on a seven-game unbeaten league run.
Ederson is fit to return between the posts for Manchester City when they welcome Chelsea to the Etihad, as fourth play host to third.
Leicester will be hoping to win their sixth match in a row when they travel to the AMEX Stadium to face Brighton this weekend.
Liverpool head to London looking to extend their unbeaten run at the start of the season to 13 games and clinch a sixth successive win at Selhurst Park.
Arsenal take on Southampton at the Emirates on Saturday with both sides in need of a victory.
Jose Mourinho makes his Premier League return on Saturday as the new Tottenham Hotspur manager takes his side to West Ham United.