The pressure will be on both Manchester United and Manchester City when they meet in Wednesday's derby at Old Trafford.
Arsenal will be looking to get their top-four hopes back on track when they visit Wolves in the Premier League on Wednesday.
There will be a lot at stake in North London on Tuesday when top-four hopefuls Tottenham play host to relegation-threatened Brighton.
Southampton can go a long way to guaranteeing their Premier League status if they win at FA Cup finalists Watford on Tuesday.
Manchester United continue their quest for a top-four finish when they travel to Everton on Sunday afternoon.
Brighton go in search of a much-needed three points on Saturday when they make the trip to Molineux to take on Wolves.
Manchester City will be looking to move back to the Premier League summit on Saturday when they play host to Tottenham Hotspur.
Arsenal will look to maintain their top-four challenge when they welcome Crystal Palace to the Emirates on Sunday.
Liverpool go in search of a crucial three points when they make the trip to Cardiff City on Sunday.
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Eddie Howe will take charge of his 500th match as a manager when Bournemouth host Fulham on Saturday afternoon.
Newcastle could cross the 40-point mark with a win over Southampton, who will leapfrog the Magpies with victory at St James' Park.
It's 11th versus seventh at the London Stadium on Saturday, with West Ham looking to avoid a fourth straight league defeat.
Huddersfield will look to end a six-game losing run when they play host to Watford, who will be without skipper Troy Deeney.
Chelsea will look to continue their remarkable run in the Europa League when they welcome Slavia Prague to Stamford Bridge on Thursday.
Arsenal will be looking to reach the final four of the Europa League for the second year in a row as they prepare to take on Napoli.
Manchester City will attempt to recover from a 1-0 first-leg defeat when they host Premier League rivals Spurs in the Champions League.
Liverpool go to Porto in the last eight of the Champions League with the tie very much in their favour after a 2-0 first-leg win.
Manchester United know they must overcome a first-leg deficit if they are to knock Barcelona out of the Champions League on Tuesday.
The nerves will be jangling at The Amex on Tuesday when Brighton play host to Cardiff in a Premier League relegation six-pointer.
Southampton will hope Wolves are still suffering from their post-Wembley blues when the pair meet at St Mary's on Saturday.
Manchester City will aim to make it nine Premier League wins in a row when they travel to Crystal Palace on Sunday.
Liverpool will look to end an eight-game run without a victory over Chelsea at Anfield when the teams meet on Merseyside on Sunday.
Tottenham will be without Harry Kane for their clash with Huddersfield and Dele Alli faces a late fitness test ahead of the game.
Manchester United will be looking to improve on a recent run of one win in five when West Ham visit in Saturday's late game.
Burnley will go in search of a third consecutive Premier League win when they play host to Cardiff, who remain five points from safety.
Marco Silva's Everton can boost their push for seventh place when they travel to relegated Fulham.
Brighton have lost their last three to flirt with the relegation places but can take a step towards survival by beating Bournemouth.
Leicester City welcome Newcastle United to the King Power Stadium on Friday evening as they look to consolidate seventh in the table.
In one of the ties of the Europa League last-eight, Arsenal will look to make home advantage count against Napoli on Thursday.
Chelsea will go looking to add to their brilliant away record in the Europa League when they head to Slavia Prague on Thursday.
Manchester United boss Ole Gunnar Solskjaer could be without four first-team players for Wednesday's meeting with Barcelona.
Liverpool will be looking to take a giant step towards the semi-finals of the Champions League when they host Porto on Tuesday.
Tottenham and Manchester City will meet in the first-leg of their Champions League quarter-final tie in North London on Tuesday.
Rafa Benitez's Newcastle United will be hoping to move one step closer to safety when they take on Crystal Palace this weekend.
Huddersfield play their first match since their relegation from the Premier League was confirmed when they host Leicester on Saturday.
A place in the FA Cup final is up for grabs when in-form duo Watford and Wolves meet at Wembley Stadium on Sunday.
Burnley will be looking to ease their relegation fears when they head to the Vitality Stadium to take on Bournemouth on Saturday.
Arsenal can move back into third place when they travel to a resurgent Everton side in Sunday's sole Premier League game.
Manchester City's quest for the quadruple continues on Saturday when they face Brighton in the FA Cup semi-finals at Wembley.
Liverpool will be looking to move back to the top of the Premier League when they make the trip to Southampton on Friday.