Chelsea will be looking to secure their first win of the Frank Lampard era when they welcome Leicester to Stamford Bridge on Sunday.
Sheffield United will play their first Premier League match on home soil in over 12 years when they take on Crystal Palace on Sunday.
Pep Guardiola is expected to recall Sergio Aguero back into his starting XI for Manchester City's home clash with Tottenham.
Everton will go in search of a fifth consecutive Premier League home victory when they play host to Watford on Saturday afternoon.
Pierre-Emile Hojbjerg is set to return to Southampton's squad for Saturday's home clash with Liverpool, who have goalkeeping concerns.
Norwich and Newcastle will be hoping to get off the mark for the new season when they meet at Carrow Road on Saturday.
Brighton will be looking to make it two wins from two in the Premier League when they welcome West Ham to The Amex on Saturday.
Aston Villa's first home game back in the Premier League will see them welcome Bournemouth to Villa Park on Saturday.
Arsenal will be hoping to maintain their impressive record against Burnley when the two teams meet at Emirates Stadium on Saturday.
#mcfc could scupper rivals #mufc after offer a deal for Old Trafford defensive target tinyurl.com/nbjycws
#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
Friendly cash bonus for #mcfc tinyurl.com/nwvap9s
No plan for #mufc upgrade that Van Gaal was seeking tinyurl.com/ntqlklz
#burnley make their first signing of the summer with a swoop on #avfc tinyurl.com/nzjolto
#lcfc star set for talks over new Leicester contract tinyurl.com/plrnbpq
Agent claims #LFC interest in Ligue 1 defender tinyurl.com/q7kbpu7
Leicester City get their Premier League season underway on Sunday when they welcome Wolves to the King Power Stadium.
Manchester United wrap up the opening weekend of the Premier League when they play host to Chelsea on Sunday in the late kick-off.
Tottenham will kick off their new Premier League campaign without Son Heung-min, as they prepare to face Aston Villa on Saturday.
Steve Bruce's Newcastle United managerial reign gets underway on Sunday, when Arsenal make the trip to St James' Park.
Burnley kick off their Premier League campaign on Saturday when they welcome Southampton to Turf Moor.
Javi Gracia has revealed that Danny Welbeck is unlikely to feature in Watford's season-opener against Brighton at Vicarage Road.
Manchester City start their Premier League defence with a trip to the London Stadium to take on West Ham United this Saturday.
Roy Hodgson has confirmed Wilfried Zaha will be in the Crystal Palace squad to face Everton, despite handing in a transfer request.
Bournemouth will be without a number of key first-team players when they play host to Premier League new boys Sheffield United.
Jurgen Klopp feels the Premier League title race will be "closer" between a number of teams, as he prepares his team to face Norwich.
Wolves take a 2-0 lead to Seaview as they look to see off the Crusaders and reach the next stage of Europa League qualifying.