Interim boss Mark Hudson faces a baptism of fire on Sunday when Huddersfield host Manchester City.
Arsenal are hoping to have Hector Bellerin and Nacho Monreal back in time for Saturday’s meeting with Chelsea.
Newcastle will assess Ciaran Clark and Jamaal Lascelles ahead of Saturday’s home clash with Cardiff.
Wolves will need to cope without ever-present defender Willy Boly for Saturday’s home clash with Leicester.
Claudio Ranieri will make a late decision on whether new signing Ryan Babel is fit enough to start against Tottenham on Sunday.
Jurgen Klopp is facing a number of defensive issues ahead of Liverpool's home clash with Crystal Palace on Saturday.
Bournemouth will hand a late fitness test to striker Callum Wilson ahead of the clash with West Ham at the Vitality Stadium.
Ole Gunnar Solskjaer will look to further strengthen his claim for the managerial post at Manchester United when they host Brighton.
Southampton will be able to call on striker Danny Ings for Saturday's home clash with an Everton side back in the top half of the table.
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Watford will look to complete a league double over Burnley when the two teams meet at Vicarage Road on Saturday.
Southampton boss Ralph Hasenhuttl will be without a number of first-team stars for the third-round FA Cup replay with Derby County.
Newcastle head to Ewood Park on Tuesday to take on Championship side Blackburn in an FA Cup third-round replay.
Just goal difference separates Everton and Bournemouth going into Sunday's clash at Goodison Park, with the teams sat 11th and 12th.
Manchester City will be confident of maintaining their impressive run of form when Wolves travel to the Etihad Stadium on Monday night.
Leicester will look to make it four league wins in five games, when they host Southampton at the King Power Stadium on Saturday.
Chelsea will be looking to pile the misery on Newcastle United when the two go head-to-head at Stamford Bridge on Saturday.
Chris Hughton feels Liverpool are the Premier League title favourites, as he prepares his Brighton team to face the leaders.
Crystal Palace are aiming to move further away from the drop zone when Watford make the trip to Selhurst Park on Saturday.
West Ham United face a tricky clash on Saturday when they welcome Arsenal to the London Stadium for Premier League action.
Burnley will be hoping to continue their good run of form when they welcome relegation rivals Fulham to Turf Moor on Saturday.
Ole Gunnar Solskjaer is aiming for win number six on Sunday when Manchester United travel to Wembley to take on Tottenham.
Huddersfield boss David Wagner has described Saturday's clash at Cardiff City as a 'must-win game' for his side.
Manchester City will look to lay down a marker when they host Burton Albion in the EFL Cup semi-final first leg at the Etihad Stadium.
Tottenham and Chelsea go head-to-head at Wembley Stadium on Tuesday night in the first leg of their Carabao Cup semi-final tie.
Wolves will aim to knock Liverpool out of the FA Cup for the second time in three seasons, when the sides meet at Molineux on Monday.
Leicester will be hoping to avoid an embarrassing loss when they travel to Newport County in the third round of the FA Cup.
David Wagner has admitted he will use "fresh players" for Huddersfield's FA Cup trip to Championship side Bristol City on Saturday.
Rafael Benitez has challenged his fringe players to step up when Newcastle host Blackburn in round three of the FA Cup.
Gillingham will attempt to cause an upset when they welcome Cardiff to Priestfield for Saturday's FA Cup third-round tie.
Crystal Palace boss Roy Hodgson says he will rotate his starting line-up for Saturday's FA Cup third-round tie with Grimsby.
Non-league Woking have the chance to claim one of the biggest victories in the club's history when they host Watford in the FA Cup.
Samir Nasri could make his debut for West Ham when Birmingham City are the visitors to the London Stadium on Saturday.
Manchester City will hope to avoid an upset as they make their 2018-19 FA Cup bow against Rotherham on Sunday.
Everton welcome League Two side Lincoln City to Goodison Park on Saturday in round three of the FA Cup.
The highly-rated Callum Hudson-Odoi could be handed a rare first-team start for Chelsea when they face Nottingham Forest on Saturday.
Blackpool face Arsenal for the second time this season when they clash in round three of the FA Cup on Saturday.
League Two Oldham will look to take a Premier League scalp when they travel to relegation-threatened Fulham in the FA Cup.
Burnley could welcome back three long-term injury victims for their FA Cup third-round meeting with Barnsley at Turf Moor.
Frank Lampard's Derby will look to cause another cup upset when they play host to Premier League Southampton on Saturday.
Eddie Howe has confirmed he will make changes to his Bournemouth side for Saturday's FA Cup game against Brighton.
Ole Gunnar Solskjaer has revealed that Romelu Lukaku and Alexis Sanchez will start Saturday's FA Cup clash with Reading on Saturday.
The third round of the FA Cup kicks off on Friday night as Tottenham travel to Prenton Park to face League Two side Tranmere.
Liverpool will look to extend their lead at the top of the Premier League table to nine points when they take on Manchester City.
Manchester United's revival under Ole Gunnar Solskjaer will be put to the test when they visit Newcastle on Wednesday.
In-form Wolves are looking to make it back-to-back wins in the Premier League when they host Crystal Palace on Wednesday.
Mid-table West Ham and Brighton are set to go head-to-head at the London Stadium on Wednesday night.
Two of the bottom three will meet at the John Smith's Stadium on Wednesday when Huddersfield play host to Burnley.
Chelsea will be looking to make it three wins from three in the Premier League in Wednesday's home clash with Southampton.
Out-of-form Bournemouth will be looking to return to winning ways when they play host to Watford on Wednesday.
Arsenal have endured a difficult festive period but they will hope to return to winning ways against Fulham on New Year's Day.