Hosts Russia got off to a flyer on Thursday and will be keen to build on their World Cup momentum on Tuesday against Egypt.
Poland and Senegal get their campaigns underway on Tuesday, and, with so much to play for in Group H, this could be a thriller.
Group H kicks off on Tuesday and quarter-finalists in 2014, Colombia, will be looking to lay down a marker against Japan.
Germany begin the defence of their World Cup against Mexico on Sunday hoping for a repeat of their 2017 Confederations Cup clash.
Pre-tournament favourites Brazil will be aiming to hit the ground running in Group E when they face Switzerland in Rostov.
Costa Rica will hope to start another run to the World Cup quarter-finals when they face Serbia in Sunday's Group E opener in Samara.
Croatia and Nigeria will be aiming to get off to a flyer in World Cup Group D when they meet on Saturday in Kaliningrad.
Argentina are the favourites to top Group D but could face a stern opening test against Iceland.
With France the favourites in Group C, both Peru and Denmark will be keen to get off to a fast start on Saturday in Saransk.
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France head into the World Cup as one of the favourites and will be looking to lay down a marker on Saturday against Australia.
Egypt and Uruguay kick off Friday's action at the 2018 World Cup as they conclude the Group A games in Ekaterinburg.
Spain will be hoping their managerial upheaval doesn't impact on their performance when they face Portugal in Sochi.
Morocco and Iran meet for the first time at a World Cup on Friday as they look to make a positive start to their campaign in Group B.
Hosts Russia will hope to begin their World Cup 2018 campaign with a Group A victory over Saudi Arabia on Thursday.
Gareth Southgate has one final opportunity to assess his squad when England host Costa Rica at Elland Road on Thursday.
Morocco will continue their World Cup preparation by taking on Slovakia on neutral soil in Switzerland this evening.
New Italy manager Roberto Mancini has rung the changes for tonight's friendly with Holland in Turin.