Manchester United will be hoping to put their midweek European exit behind them when they take on Brighton in the FA Cup.
Wigan are looking for another Premier League scalp when they host Southampton in the FA Cup on Sunday.
Leicester will be looking to take advantage of Chelsea's poor form when they clash in the FA Cup quarter-finals on Sunday.
Swansea could end Tottenham's final chance of lifting a trophy this season when they meet in the FA Cup on Saturday.
Liverpool could move up to third in the Premier League if they can claim the three points against Watford on Saturday evening.
West Brom head to the south coast to face Bournemouth on Saturday, looking to league double over the Cherries this season.
It's 15th vs 18th at the John Smith's Stadium on Saturday, as Huddersfield and Crystal Palace meet in a crucial battle at the bottom.
Stoke will move out of the Premier League relegation zone if they can beat Everton at the bet365 Stadium on Saturday afternoon.
Arsenal boss Arsene Wenger has a number of selection headaches ahead of the game against Milan in the UEFA Europa League.
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Chelsea travel to the Nou Camp on Wednesday night looking to get the better of Barcelona in the Champions League last-16, second-leg.
Manchester United are sweating over the fitness of Paul Pogba for Tuesday's Champions League clash with Sevilla.
Stoke City have the chance to climb out of the relegation zone on Monday night but will be up against it against Manchester City.
Tottenham will be seeking to put their Champions League disappointment behind them when they travel to Bournemouth on Sunday.
West Ham boss David Moyes will look for his team to bounce back from successive heavy losses when they face Burnley on Saturday.
Chelsea will need to show more attacking intent if they are to keep their top-four bid alive when they face Crystal Palace on Saturday.
There's a Midlands derby at the Hawthorns on Saturday, with West Brom against Leicester looking like a must-win clash for the Baggies.
Arsenal will look to build on their much-needed win over AC Milan when they return to domestic action against Watford on Sunday.
There's always been a huge rivalry between Man Utd and Liverpool and even more so when the two teams are second and third in the table.
It's fifth from bottom against fourth from bottom at St James' Park on Saturday afternoon, as Newcastle welcome Southampton.
Swansea head to the John Smith's Stadium to face Huddersfield on Saturday, looking to do the league double over the Terriers.
Two teams sat in mid-table on the same points meet at Goodison Park, as Everton and Brighton clash on Saturday afternoon.
AC Milan will be looking to take advantage of a wounded Arsenal in their Europa League last-16 first-leg clash on Thursday.
Tottenham will host Juventus in the second-leg of their Champions League last 16 tie on Wednesday with everything still to play for.
Manchester City are all but assured of their place in the quarter-finals of the Champions League ahead of their clash with Basel.
Jurgen Klopp says he will keep changes to a minimum when Liverpool host Porto in the Champions League last-16 second leg.
Crystal Palace will be looking to climb out of the bottom three on Monday when they host Manchester United in the Premier League.
Manchester City will look to take another step towards the title when they welcome Chelsea to the Etihad Stadium on Sunday.
Arsenal travel to Brighton on Sunday looking to bounce back from consecutive defeats to Manchester City.
Crystal Palace will be looking to boost their survival hopes when Manchester United travel to Selhurst Park on Monday.
Liverpool will look to continue their recent strong form in Saturday's late game against Newcastle at Anfield.
Bottom club West Brom travel to Watford on Saturday hoping to claim a crucial three points after being cut adrift.
Tottenham will expect to continue their fine home form when Huddersfield visit Wembley on Saturday afternoon.
Swansea will be looking to make the most of West Ham's away day woes when the pair meet at the Liberty Stadium on Saturday.
Relegation rivals Southampton and Stoke meet at St Mary's in a game that could define both side sides' futures.
Leicester and Bournemouth meet at the King Power on Saturday and both will be keen to put their recent unpredictable runs behind them.
Burnley welcome Everton to Turf Moor in Saturday's early match with both sides heading into the game on the back of disappointing runs.
Arsenal will be desperate to bounce back from a humiliating Carabao Cup final defeat when they host Manchester City on Thursday.
Mauricio Pochettino has admitted he will rotate his Tottenham squad for Wednesday's FA Cup replay against Rochdale at Wembley.
Carlos Carvalhal prepares to take on his former club again on Tuesday, as Swansea face Sheffield Wednesday in their FA Cup replay.
Leon Britton will rejoin the Swansea squad for the FA Cup fifth round replay at home to Sheffield Wednesday on Tuesday night.