Liverpool will look to extend their lead at the top of the Premier League table when they welcome rivals Manchester City to Anfield.
Wolves will look to extend their unbeaten run to three matches when they face local rivals Aston Villa this weekend.
Brighton will look to win their third game in a row when they travel to Old Trafford to take on Manchester United.
Leicester will look to win their fifth game in a row when they welcome Arsenal to the King Power Stadium on Saturday.
Two teams under severe pressure at the bottom end of the table meet at St Mary's, as Southampton and Everton go head-to-head.
Tottenham can go level on points with Sheffield United if they claim victory against the Blades on Saturday afternoon.
Chelsea will look to make it six league wins on the spin when they play host to Crystal Palace at Stamford Bridge on Saturday.
A win for Bournemouth over Newcastle at St James' Park on Saturday could move the Cherries into the Premier League top six.
Burnley and West Ham United will both be looking to get back to winning ways when they meet at Turf Moor on Saturday.
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Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
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Norwich City welcome Watford to Carrow Road for Friday night football in a crucial bottom-of-the-table Premier League encounter.
Tottenham are aiming for back-to-back Champions League wins over Red Star when they travel to Belgrade on Wednesday.
Arsenal boss Unai Emery is set to revert to his usual Europa League side for Wednesday's game at Vitoria Guimaraes.
Manchester City will be expected to make it four wins from four in the Champions League at Atalanta on Wednesday.
Both Everton and Tottenham will be hoping they can kick-start their seasons when they meet at Goodison Park on Sunday.
Crystal Palace will be hoping to contain in-form Leicester when the teams meet at Selhurst Park in the Premier League on Sunday.
Watford face a tough challenge if they are to secure their first Premier League win of the season against in-form Chelsea on Saturday.
Manchester City and Southampton will meet for the second time in the space of four days at the Etihad Stadium on Saturday.
Aston Villa will have a mountain to climb on Saturday when they attempt to end Liverpool's unbeaten run in the Premier League.
Brighton welcome Norwich to the Amex Stadium on Saturday with the Seagulls gunning for a third-straight home win.
Goal-shy Bournemouth will be looking to curtail Manchester United's recent return to form when the two teams meet on Saturday.
Asenal will seek to put a tumultuous week behind them and get back to winning ways when Wolves visit the Emirates Stadium on Saturday.
West Ham are hoping to bounce back to winning ways when Newcastle travel to the London Stadium on Saturday.
Sheffield United will look to continue their fine start to the season when they welcome Burnley to Bramall Lane on Saturday.