All eyes will be on the team-sheets when Everton and Crystal Palace meet in the Premier League on Sunday.
Struggling Huddersfield will be hoping to cause a surprise at the John Smith's Stadium on Saturday when they face unbeaten Liverpool.
Newcastle will be looking to secure their first victory of the season when they welcome Brighton to St James' Park on Saturday.
Chelsea and Manchester United renew rivalries when they meet at Stamford Bridge in the Premier League on Saturday lunchtime.
Wolves will be looking to extend their unbeaten run in the Premier League to seven matches when they host Watford on Saturday.
Manchester City will put their imperious home record on the line when they host Burnley in the Premier League on Saturday.
Bottom face 17th on Saturday when promoted Cardiff and Fulham clash, with neither team winning any of their last five matches.
Marko Arnautovic and Christian Eriksen will feature for their respective teams in Saturday's clash between West Ham and Tottenham.
South Coast rivals Bournemouth and Southampton meet at the Vitality Stadium on Saturday with 11 points separating the two sides.
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Tranmere will welcome back top-scorer James Norwood from suspension as they go in search of their third successive League Two win
The Republic of Ireland will look to exact some revenge on Denmark when they meet in the Nations League in Dublin on Saturday.
Croatia and England will renew their rivalry in the UEFA Nations League behind closed doors on Friday night.
Austria and Northern Ireland are both aiming for their first points in the UEFA Nations League when they clash in Vienna on Friday.
Scotland will look to kick on from their winning start in Nations League C Group 1 when they face Israel on Thursday.
Wales will be missing talisman Gareth Bale when they play host to Spain in Thursday's international friendly in Cardiff.
Tottenham will be seeking to put their Champions League loss to Barcelona behind them when they play host to Cardiff on Saturday.
Arsenal could seal nine wins in a row when they make the short trip across London to face a struggling Fulham side on Sunday.
Southampton will look to win just a second Premier League home game of 2018 when they play host to Chelsea on Sunday afternoon.
Crystal Palace will go in search of their first home win of the season when they play host to in-form Wolves on Saturday.
Victory for Everton on Saturday would take them level on points with Leicester but the Foxes are eyeing a third consecutive win.
Manchester United could slip into the bottom half of the table if they fail to beat Newcastle following their worst start in 29 years.
The top two in the Premier League meet on Sunday with a win leaving the victors as league leaders going into the international break.
Huddersfield make the trip across the Pennines on Saturday to take on Burnley still searching for their first win of the season.
It's sixth against seventh at Vicarage Road as Watford look to extend a six-game unbeaten run in fixtures against Bournemouth.
Brighton will be looking to end their six-match winless run when they welcome West Ham to the Amex Stadium on Friday night.
Chelsea will fancy their chances of making it two wins from two in this season's Europa League when they play host to Vidi on Thursday.
Ibrox will host European group stage football for the first time since 2011 when Rangers entertain Rapid Vienna on Thursday.
Arsenal will be looking to extend their winning run to eight matches in all competitions when they visit Qarabag in the Europa League.
Celtic's Europa League credentials will be put to the test when they travel to Austria to take on Salzburg in Group B on Thursday.
Liverpool will aim to maintain their good start to the season when they take on Napoli in Wednesday's Champions League Group C clash.
Tottenham will aim to bounce back from an opening Group B defeat when La Liga giants Barcelona arrive at Wembley on Wednesday.
Manchester United will be hoping for some European relief on Tuesday when they welcome Valencia to Old Trafford.
Manchester City will be hoping to get off the mark in the Champions League on Tuesday when they make the trip to Hoffenheim.
Everton and Southampton turn their attentions to the Carabao Cup on Tuesday when they go head-to-head at Goodison Park.
Bournemouth will be aiming to continue their positive start to the season when Crystal Palace travel to the Vitality Stadium on Monday.