West Ham look like they have work to do as they prepare to face Bournemouth in their first home game of the Premier League.
Tottenham head back to Wembley as Fulham cross the capital on Saturday afternoon.
Brighton are likely to make changes when they welcome Manchester United to the Amex on Sunday.
Manchester City will tackle Huddersfield on Sunday without Kevin de Bruyne, who has been sidelined for three months with a knee injury.
Chelsea's Eden Hazard is expected to start Saturday night's clash with Arsenal, who are set to stick with Petr Cech between the posts.
Burnley will hope fatigue is not a factor when they welcome Watford to Turf Moor on Sunday.
Two teams that drew their opening Premier League games last weekend meet at Goodison Park as Everton and Southampton go head-to-head.
Leicester prepare to face Wolves in a Midlands derby with Claude Puel insisting his future remains at the King Power Stadium.
Cardiff welcome Newcastle in Saturday's early game, with both sides eyeing a first Premier League win of the season.
#mcfc could scupper rivals #mufc after offer a deal for Old Trafford defensive target tinyurl.com/nbjycws
#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
Friendly cash bonus for #mcfc tinyurl.com/nwvap9s
No plan for #mufc upgrade that Van Gaal was seeking tinyurl.com/ntqlklz
#burnley make their first signing of the summer with a swoop on #avfc tinyurl.com/nzjolto
#lcfc star set for talks over new Leicester contract tinyurl.com/plrnbpq
Agent claims #LFC interest in Ligue 1 defender tinyurl.com/q7kbpu7
Burnley welcome Istanbul Basaksehir back to Turf Moor on Thursday for the second leg of their Europa League third qualifying round tie.
Jurgen Klopp has dismissed talk that Liverpool are favourites for the title ahead of their season opener against West Ham on Sunday.
Mark Hughes begins his first full season in charge of Southampton at home to Burnley on Sunday.
Manchester City get their Premier League title defence underway on Sunday when they take on Arsenal at the Emirates.
Wolves will play their first Premier League game since 2012, when they play host to Everton at Molineux on Saturday evening.
Bournemouth and Premier League new boys Cardiff are preparing to face each other for the first time in top-flight history.
Newly-promoted Fulham kick off their Premier League campaign at home to Crystal Palace on Saturday afternoon.
Newcastle United and Tottenham Hotspur go head-to-head at St James' Park on Saturday in their Premier League opener.
Watford and Brighton will meet for only the fifth time in the top flight, with one win each and two draws in their previous encounters.
Chelsea could hand a debut to Kepa Arrizabalaga at Huddersfield, after signing the goalkeeper for a world record fee on Thursday.
New Manchester United midfielder Fred looks set to make his debut for the club during Friday's Premier League clash with Leicester.
Burnley boss Sean Dyche will have 17 fit outfield players for the Europa League third qualifying round clash at Istanbul Basaksehir.
Burnley newboys Joe Hart and Ben Gibson could make their debuts in the Europa League clash with Istanbul Basaksehir.
Chelsea and Manchester City will compete for the first piece of silverware of the season when they meet in Sunday's Community Shield.
Burnley and Aberdeen meet in their Europa League second qualifying round tie on Thursday with it all to play for at 1-1.
It is all to play for as Burnley prepare to face Aberdeen in the second leg of their Europa League qualifying round tie on Thursday.