Chelsea will look to continue their remarkable run in the Europa League when they welcome Slavia Prague to Stamford Bridge on Thursday.
Arsenal will be looking to reach the final four of the Europa League for the second year in a row as they prepare to take on Napoli.
Manchester City will attempt to recover from a 1-0 first-leg defeat when they host Premier League rivals Spurs in the Champions League.
Liverpool go to Porto in the last eight of the Champions League with the tie very much in their favour after a 2-0 first-leg win.
Manchester United know they must overcome a first-leg deficit if they are to knock Barcelona out of the Champions League on Tuesday.
The nerves will be jangling at The Amex on Tuesday when Brighton play host to Cardiff in a Premier League relegation six-pointer.
Southampton will hope Wolves are still suffering from their post-Wembley blues when the pair meet at St Mary's on Saturday.
Manchester City will aim to make it nine Premier League wins in a row when they travel to Crystal Palace on Sunday.
Liverpool will look to end an eight-game run without a victory over Chelsea at Anfield when the teams meet on Merseyside on Sunday.
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Tottenham will be without Harry Kane for their clash with Huddersfield and Dele Alli faces a late fitness test ahead of the game.
Manchester United will be looking to improve on a recent run of one win in five when West Ham visit in Saturday's late game.
Burnley will go in search of a third consecutive Premier League win when they play host to Cardiff, who remain five points from safety.
Marco Silva's Everton can boost their push for seventh place when they travel to relegated Fulham.
Brighton have lost their last three to flirt with the relegation places but can take a step towards survival by beating Bournemouth.
Leicester City welcome Newcastle United to the King Power Stadium on Friday evening as they look to consolidate seventh in the table.
In one of the ties of the Europa League last-eight, Arsenal will look to make home advantage count against Napoli on Thursday.
Chelsea will go looking to add to their brilliant away record in the Europa League when they head to Slavia Prague on Thursday.
Manchester United boss Ole Gunnar Solskjaer could be without four first-team players for Wednesday's meeting with Barcelona.
Liverpool will be looking to take a giant step towards the semi-finals of the Champions League when they host Porto on Tuesday.
Tottenham and Manchester City will meet in the first-leg of their Champions League quarter-final tie in North London on Tuesday.
Rafa Benitez's Newcastle United will be hoping to move one step closer to safety when they take on Crystal Palace this weekend.
Huddersfield play their first match since their relegation from the Premier League was confirmed when they host Leicester on Saturday.
A place in the FA Cup final is up for grabs when in-form duo Watford and Wolves meet at Wembley Stadium on Sunday.
Burnley will be looking to ease their relegation fears when they head to the Vitality Stadium to take on Bournemouth on Saturday.
Arsenal can move back into third place when they travel to a resurgent Everton side in Sunday's sole Premier League game.
Manchester City's quest for the quadruple continues on Saturday when they face Brighton in the FA Cup semi-finals at Wembley.
Liverpool will be looking to move back to the top of the Premier League when they make the trip to Southampton on Friday.
Chelsea will be hoping to keep the pressure on their top four rivals by beating Brighton at Stamford Bridge on Wednesday.
Manchester City can move back to the top of the Premier League standings by beating struggling Cardiff at the Etihad on Wednesday.
Tottenham will be looking to begin life at their new stadium by beating Crystal Palace in the Premier League on Wednesday night.
Scott Parker says Fulham striker Aleksandar Mitrovic remains a doubt for Tuesday's Premier League clash at Watford.
Having knocked Manchester United out of the FA Cup, Wolves could seriously dent the Red Devils' top-four bid on Tuesday.
Arsenal will look to make it 10 successive home Premier League victories when they host Newcastle on Monday.
Liverpool will look to extend their impressive home league record when Tottenham come to town on Sunday.
Huddersfield could be relegated from the Premier League this weekend if they lose at Crystal Palace and other results go against the Terriers.
Cardiff will look to claim their first top-flight win over Chelsea since 1961 when they go head-to-head on Sunday.
Manchester City can return to the top of the Premier League table if they continue their winning form at struggling Fulham on Saturday.
Burnley will attempt to boost their survival hopes on Saturday when they welcome Wolves to Turf Moor.
Ole Gunnar Solskjaer will take charge of his first game as permanent Man Utd manager when the Red Devils face Watford on Saturday.
Leicester will look to claim a victory over Bournemouth for the first time in the Premier League when the two teams meet on Saturday.
The London Stadium is the venue for ninth against 11th on Saturday evening, when West Ham play host to Everton.
Two teams battling to survive in the Premier League meet at the Amex Stadium on Saturday, as Brighton and Southampton clash.