Crystal Palace travel to Doncaster Rovers on Sunday as both teams battle it out for place in the quarter-finals of the FA Cup.
Newport will be looking to cause a huge upset on Saturday when they play host to Manchester City in the fifth round of the FA Cup.
It's likely to be a fiercely fought FA Cup fifth round tie at Ashton Gate on Sunday afternoon, when Bristol City and Wolves collide.
Chris Hughton has called on his Brighton players to consider Derby as a Premier League team, ahead of their FA Cup fifth round meeting.
Two teams just 20 miles apart meet at Loftus Road on Friday night, as QPR and Watford clash in the fifth round of the FA Cup.
Arsenal head to BATE for the first leg of their Europa League last-32 tie looking to pick up from where they left off in Europe.
Valencia travel to Celtic for their Europa League last-32 clash aiming to become just the second team to win at Parkhead this season.
Chelsea will bid to banish memories of Sunday's thrashing at Man City when they travel to Malmo in the Europa League last-32.
Tottenham face familiar European rivals Borussia Dortmund at Wembley in Wednesday's Champions League last-16, first-leg tie.
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Wolves will be chasing their first league double over Newcastle in 27 years when the teams meet at Moilneux on Monday.
Manchester United will be looking to take advantage of Paris Saint-Germain's injury troubles when the teams meet on Tuesday.
Manchester City will be looking for revenge when they welcome Chelsea to the Etihad in Sunday's late game.
Leicester midfielder Youri Tielemans could make his debut in Sunday’s clash with Tottenham at Wembley.
It's 16th against 18th at St Mary's on Saturday, as Southampton and Cardiff meet in a crucial clash at the bottom end of the table.
Marco Silva will be the centre of attention when his current club Everton face his old team Watford at Vicarage Road on Saturday.
January arrival Denis Suarez could make his full debut for Arsenal when they travel to Huddersfield on Saturday.
Liverpool know a win at home to Bournemouth on Saturday will take them back to the top of the table with Man City playing on Sunday.
Crystal Palace can call on influential winger Wilfried Zaha for Saturday’s home clash with West Ham.
Five of the last six meetings between Brighton and Burnley have been draws, as the pair prepare to meet again on Saturday night.
Fulham will attempt to land a first Premier League defeat on Ole Gunnar Solskjaer when they host Manchester United on Saturday.
Manchester City can reclaim top spot in the Premier League with a win over beleaguered Everton at Goodison Park on Wednesday.
Wolves take on Shrewsbury Town at Molineux on Tuesday night for a place in the fifth round of the FA Cup.
Manchester City will look to continue their superb recent record against Arsenal when the teams meet on Sunday in the Premier League.
Leicester will be looking to pull off another shock result when they welcome Manchester United to the King Power Stadium on Sunday.
Crystal Palace boss Roy Hodgson looks set to hand Michy Batshuayi a debut as his side welcome Fulham to Selhurst Park on Saturday.
Cardiff City will be looking to move closer to Premier League safety when they welcome Bournemouth to Wales on Saturday.
Brighton will be looking to end a run of four games without victory when they welcome Watford to the Amex Stadium on Saturday.
Peter Crouch could make his Burnley debut against former club Southampton on Saturday after sealing his move on deadline day.
Maurizio Sarri read his Chelsea squad the riot act in midweek and will be looking for a response against Huddersfield on Saturday.
Everton will hand a late fitness test to Idrissa Gana Gueye ahead of Saturday's clash with Wolves at Goodison Park.
Tottenham will be keen to continue their title push when they welcome Newcastle to Wembley in Saturday's early match.
Southampton hope Matt Targett recovers from a knee injury to be fit to face Crystal Palace on Wednesday.
Virgil van Dijk is a doubt for Liverpool's home game against Leicester on Wednesday as the centre-back has been ill.
Bournemouth's Callum Wilson is a doubt for Chelsea's visit as Gonzalo Higuain gears up to make his Premier League debut.
Tottenham will look to bounce back from consecutive cup exits when they host Watford in the Premier League on Wednesday.
Fulham will be hoping to reignite their Premier League survival bid when they welcome Brighton to Craven Cottage on Tuesday.
Cardiff staff and supporters will wear yellow daffodils at Arsenal on Tuesday, as a mark of respect for striker Emiliano Sala.
Wolves and West Ham will be looking to bounce back from disappointing results in the FA Cup when they meet at Molineux on Tuesday.
Newcastle and Manchester City need Premier League points for very different reasons ahead of their clash at St James' Park on Tuesday.
Jan Siewert will take charge of Huddersfield for the first time when they play host to Everton in the Premier League on Tuesday.
Ole Gunnar Solskjaer will be chasing his ninth straight win as Manchester United manager when Burnley visit Old Trafford on Tuesday.