England will be looking to get their Euro 2020 qualifying campaign back on track when they take on Bulgaria in Sofia on Monday.
Southampton have claimed just one point at home so far this term and now face a stiff test against an ever-improving Chelsea team.
Pep Guardiola admits his team's home form has to be good in order to retain the title, as Man City prepare to face Wolves on Sunday.
Everton will go in search of their first Premier League away win of the season when they travel to Turf Moor to face Burnley.
Arsenal will look to continue their impressive form when they welcome Bournemouth to the Emirates on Sunday for Premier League action.
Newcastle United bid to move out of the relegation zone on Sunday when they welcome Manchester United to St James' Park.
Watford go in search of their first win of the Premier League season on Saturday when they welcome Sheffield United to Vicarage Road.
Carrow Road is the venue for a potential relegation six-pointer on Saturday as Norwich City play host to Aston Villa.
A mouth-watering clash takes place at Anfield on Saturday when table-toppers Liverpool take on third-place Leicester City.
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#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
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West Ham will look to extend their unbeaten run to seven matches when they welcome Crystal Palace to the London Stadium.
Brighton will look to win their first game since the opening weekend of the season when they welcome Tottenham to the AMEX Stadium.
Manchester United will be looking to cement their position at the top of Group L when they make the Europa League trip to AZ Alkmaar.
Wolves go in search of their first Europa League points of the season on Thursday evening when they make the trip to Besiktas.
Arsenal welcome Standard Liege to the Emirates on Thursday evening for their second match in Europa League Group F.
Liverpool welcome Salzburg to Anfield looking to try and win their first Champions League match of the season.
Chelsea travel to Lille aiming to grab their first win of the Champions League this season after their Valencia disappointment.
Manchester City will be looking to make it two wins from two in the Champions League when they play host to Dinamo Zagreb on Tuesday.
Tottenham will face a stern test of their Champions League credentials when host Bayern Munich on Tuesday.
Manchester United will be looking to get their Premier League season back on track when they play host to Arsenal on Monday night.
Aston Villa go in search of just their second win of the Premier League season, when they play host to Burnley on Saturday afternoon.
Tottenham will look to put a bad week behind them when Mauricio Pochettino's old club Southampton visit north London on Saturday.
Crystal Palace are waiting on news of Mamadou Sakho's injury ahead of Saturday's visit of Norwich.
Sheffield United are the latest team trying to end Liverpool's 100% league record when the teams meet in Saturday's early kick-off.
Top-six hopefuls Bournemouth and West Ham meet on Saturday in a match both will fancy their chances of winning.
The Premier League's bottom two sides meet on Saturday as Wolves host Watford at Molineux.
Saturday's late game in the Premier League sees Everton host Manchester City and both sides are in need of the points.
Chelsea will be searching for their first league win at Stamford Bridge this season when Brighton make the trip to the capital on Saturday.