Manchester City will look to complete a unique treble in Saturday's clash with Watford, who are seeking their first FA Cup success.
Leicester City will attempt to complete the league double over Chelsea for the first time since the 2000-01 campaign on Sunday.
Burnley will look to end a run of nine straight defeats against Arsenal in all competitions when they host the Gunners on Sunday.
Scott Parker's first match since being put in permanent charge of Fulham could be counterpart Rafa Benitez's last game as Newcastle boss.
Man City could be boosted by the return of Kevin De Bruyne as they target the win that will ensure them of the title at Brighton.
Southampton play host to relegated Huddersfield Town at St Mary’s with little to play for in the final game of the season.
Watford host West Ham United at Vicarage Road in the Hornets’ last match before their FA Cup final against Manchester City.
Tottenham will need to refocus as they end their Premier League season at home against Everton following a miraculous week for the club.
Liverpool will be going all out for the win over their FA Cup conquerors Wolves while they will be hoping Brighton can do them a favour.
#mcfc could scupper rivals #mufc after offer a deal for Old Trafford defensive target tinyurl.com/nbjycws
#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
Friendly cash bonus for #mcfc tinyurl.com/nwvap9s
No plan for #mufc upgrade that Van Gaal was seeking tinyurl.com/ntqlklz
#burnley make their first signing of the summer with a swoop on #avfc tinyurl.com/nzjolto
#lcfc star set for talks over new Leicester contract tinyurl.com/plrnbpq
Agent claims #LFC interest in Ligue 1 defender tinyurl.com/q7kbpu7
Crystal Palace host Bournemouth in a clash involving two mid-table teams who have achieved their yearly objectives.
Manchester United will look to end their season on a high as they take on relegated Cardiff City at Old Trafford.
Arsenal take a 3-1 lead to Valencia in their Europa League second leg fixture, but may be cautious given recent results.
Chelsea are in pole position to qualify for the final of the Europa League as they prepare to meet Eintracht Frankfurt.
Tottenham will seek to do the unlikely and overturn a 1-0 deficit on the road when they face Ajax in the Champions League on Wednesday.
Liverpool will have it all to do when they take on Barcelona in the second leg of their Champions League semi-final tie on Tuesday.