Leicester will be hoping to avoid an upset when Fleetwood visit the King Power in Tuesday's FA Cup third round replay.
West Ham welcome Shrewsbury to the London Stadium on Tuesday evening in an FA Cup third-round replay.
Manchester United will face managerless Stoke City at Old Trafford on Monday without the services of Zlatan Ibrahimovic.
Arsenal will look to extend their unbeaten Premier League run to six games, when they face Chelsea at the Emirates on Wednesday night.
Tottenham are expected to welcome Harry Kane back to the starting line up for Thursday's London derby with West Ham at Wembley.
The 230th Merseyside derby will see Liverpool play host to Everton in the FA Cup third round on Friday evening.
Manchester United will be hoping to avoid a second cup shock of the season when they play host to Derby in the FA Cup on Friday.
Jamie Vardy is a major doubt to face his former club as Leicester travel to Highbury to take on Fleetwood in the FA Cup on Saturday.
Improving Bolton will be aiming to cause an FA Cup shock when they play host to Premier League outfit Huddersfield on Saturday.
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Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
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Bournemouth will have to be on their guard when they play host to League One high-flyers Wigan in the FA Cup third round on Saturday.
Under-pressure Stoke manager Mark Hughes knows his side cannot afford anymore slips when they face Coventry in the FA Cup on Saturday.
West Brom will be hoping for a morale boosting victory when they travel to St James Park to take on Exeter in the FA Cup third round.
Fulham and Southampton will head into their FA Cup third round clash at Craven Cottage on Saturday in contrasting form.
Manchester City's domestic dominance so far this season will be put to the test when they take on Burnley in the FA Cup third round.
Newcastle enjoyed a solid festive period in the Premier League but they will be hoping to avoid an FA Cup shock against Luton.
Watford have already lost to Bristol City once this season and they will be looking to avoid a repeat when they meet in the FA Cup.
Top of the Championship takes on bottom of the Premier League as Wolves play host to Swansea in the FA Cup third round on Saturday.
Championship outfit Norwich will play host to Premier League giants Chelsea in the FA Cup third round on Saturday evening.
Managerless Nottingham Forest face the daunting prospect of playing host to holders Arsenal in the FA Cup third round on Sunday.
League One high-flyers Shrewsbury will play host to improving West Ham in the FA Cup third round on Sunday.
A much-changed Tottenham team is expected to take to the field when they play host to AFC Wimbledon in the FA Cup third round.
History will be made when Brighton play host to Crystal Palace in the third round of the FA Cup on Monday night.
Man City will continue their hunt for the quadruple on Tuesday when they face Bristol City in the Carabao Cup semi-final first leg.
Chelsea host Arsenal in the Carabao Cup semi-final first-leg on Wednesday, with the two sides meeting for the third time this season.
Bournemouth will look to move clear of the bottom three and put more pressure on Arsenal boss Arsene Wenger when they meet on Sunday.
Chelsea will look to move into the top two for the time being on Saturday as they take on Leicester City at Stamford Bridge.
New loan signing Georges-Kevin NKoudou is set to make his debut as Burnley travel to Selhurst Park to take on Crystal Palace.
Tottenham will look to extend their unbeaten run to six matches when they welcome Everton to Wembley on Saturday evening.
West Brom will look to win their first league match since August when they welcome Brighton to The Hawthorns on Saturday afternoon.
Newcastle will be looking to extend their winning run to three matches then they take on Swansea City at St James' Park on Saturday.
Huddersfield boss David Wagner could give Terence Kongolo and Alex Pritchard their league debuts against West Ham this weekend.
Southampton will look to win their first league game since November when they travel to Vicarage Road to face Watford.
Liverpool boss Jurgen Klopp will welcome back Mohamed Salah in time for Sunday's clash with Manchester City.