Manchester United and Tottenham will meet in an FA Cup tie for the 11th time, with both teams having progressed five times each.
Swansea will be looking to spoil Manchester City’s party when they travel to the Etihad Stadium on Sunday.
Stoke will be looking to win their first match in 10 attempts when they host high-flying Burnley on Sunday.
Arsene Wenger will take charge of Arsenal for the first time since he revealed he will leave the club at the end of the season.
Southampton will look to take the pressure of their relegation scrap by reaching the FA Cup final ahead of Chelsea this weekend.
Crystal Palace head to Watford knowing a win moves them to 37 points, level with the Hornets, and almost certainly safe from the drop.
West Brom could be relegated this weekend if they fail to beat Liverpool on Saturday and other results go against them.
Southampton head to Leicester on Thursday in desperate need for points as they continue to battle against relegation.
Burnley can move within five points of Chelsea if they defeat the Blues at Turf Moor on Thursday.
#mcfc could scupper rivals #mufc after offer a deal for Old Trafford defensive target tinyurl.com/nbjycws
#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
Friendly cash bonus for #mcfc tinyurl.com/nwvap9s
No plan for #mufc upgrade that Van Gaal was seeking tinyurl.com/ntqlklz
#burnley make their first signing of the summer with a swoop on #avfc tinyurl.com/nzjolto
#lcfc star set for talks over new Leicester contract tinyurl.com/plrnbpq
Agent claims #LFC interest in Ligue 1 defender tinyurl.com/q7kbpu7
Manchester United will seek to bounce back from their shock loss to West Brom when they travel to Bournemouth on Wednesday night.
Brighton claimed a heard-fought point towards safety as they held Tottenham to a 1-1 draw at the Amex.
With seven points between themselves and the drop Brighton are still in need of points as they prepare to host Tottenham on Tuesday.
West Ham welcome Stoke to the London Stadium on Monday evening with both teams in need of the points to boost their survival hopes.
Manchester United can move West Brom a step closer to the Premier League trap door when they meet at Old Trafford on Sunday.
Resurgent Newcastle will be looking to maintain their impressive form against an Arsenal side whose thoughts may be elsewhere.
Tottenham will be hoping to add to Manchester City's recent struggles when the two teams clash at Wembley on Saturday.
Relegation-threatened Southampton will play host to out-of-sorts Chelsea in the Premier League on Saturday.
Burnley can take a giant step towards a place in next season's Europa League if they can beat Leicester at Turf Moor on Saturday.
Jurgen Klopp has suggested Jordan Henderson will come straight back into Liverpool's starting XI for Saturday's clash with Bournemouth.
Huddersfield head coach David Wagner says he "cannot wait for Saturday" as Town prepare to take on Watford at the John Smith's Stadium.
Swansea go into Saturday's clash with Everton having lost just one of their last seven Premier League meetings with the Toffees.
Rivals Crystal Palace and Brighton will meet for the third time this season, when the two go head-to-head at Selhurst Park on Saturday.
Arsenal hold the advantage as they head to CSKA Moscow for the second-leg of their Europa League quarter-final tie.
Bayern Munich hold the advantage as Sevilla travel to the Allianz Arena for the second-leg of their Champions League quarter-final tie.
Defending champions Real Madrid lead Juventus 3-0 as the two giants prepare to battle it out on Wednesday at The Bernabeu.
Roma will have to overturn a three-goal deficit if they are to beat Barcelona and progress to the Champions League semi-finals.
Manchester City will look to put a bad week behind them when they try to overturn a 3-0 first-leg deficit against Liverpool.
Chelsea will seek to keep their faint top-four hopes alive when they take on relegation-threatened West Ham on Sunday.
Resurgent Arsenal will go in search of a fifth win in all competitions when they welcome Southampton to the Emirates Stadium on Sunday.
Darren Moore will take charge of West Brom for the first time in a must-win clash against fellow strugglers Swansea on Saturday.
Newcastle United will seek to further boost their survival hopes with a third successive win when they travel to Leicester on Saturday.
Manchester City will look to clinch the Premier League title when local rivals Manchester United visit the Etihad Stadium on Saturday.
Stoke will seek to end an eight-game run without a victory when they host Tottenham at the bet365 Stadium on Saturday.
Burnley will look to secure their first Premier League double over Watford, when the two teams meet at Vicarage Road on Saturday.
Three points separate Brighton and Huddersfield going into Saturday's clash, with both teams coming off the back of successive defeats.
The 231st Merseyside Derby takes place at Goodison Park on Saturday lunchtime, with Everton looking for a first win since 2010.
Bournemouth face Crystal Palace on Saturday knowing that a win will get the Cherries to the magical 40-point mark.
Striker Alexandre Lacazette could be in line to start Arsenal's Europa League quarter-final, first-leg tie with CSKA Moscow.
Liverpool and Manchester City will clash in the first-leg of their mouthwatering Champions League quarter-final tie on Wednesday.
In-form Barcelona will play host to Roma in the first-leg of their Champions League quarter-final tie at the Nou Camp on Wednesday.
Sevilla are hoping to cause an upset when they play host to Bayern Munich in the Champions League quarter-final first-leg on Tuesday.
Juventus will be hoping for revenge when playing host to Real Madrid on Tuesday in the Champions League quarter-final, first-leg tie.