In-form Celtic will look to punch their ticket for the Europa League last-32 when they welcome Salzburg to Celtic Park on Thursday.
Rangers travel to Austria knowing a win over Rapid Vienna is a must if they are to go through to the Europa League knockout stages.
Chelsea travel to Hungary to face MOL Vidi in their final Europa League group game seeking to maintain their 100 per cent record.
Arsenal will seek to sign off from the Europa League group stages with a fifth win in six matches when they face Qarabag on Thursday.
Jose Mourinho is poised to make changes for Man Utd's final Champions League group game at Valencia, with Paul Pogba set to start.
Man City boss Pep Guardiola says he has just 15 fit senior players for Wednesday Champions League game at home to Hoffenheim.
A tight Group C concludes on Tuesday when Liverpool welcome Napoli to Anfield for Champions League action.
Tottenham go in search of a Champions League last-16 spot when they take on Barcelona at the Nou Camp in Group B on Tuesday.
Marco Silva's Everton face his former club Watford at Goodison Park on Monday, with three points separating the sides.
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#saintsfc hold talks over potential Dutch deal tinyurl.com/q2adcs3
#watfordfc are leading the race to sign a Greek international defender tinyurl.com/o556yot
Former star questions #mufc wisdom in potential De Gea - Ramos deal with #RealMadrid tinyurl.com/nugomjo
#efc face another summer fight to keep a hold of a key player, with #SerieA claims tinyurl.com/qew8qpr
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Wolves head into Sunday’s Premier League clash with Newcastle on a high after ending a six-game winless run last time out.
Leicester will look to derail Tottenham’s strong start to the Premier League campaign when they clash in the East Midlands.
Ralph Hasenhuttl will take charge of his first Southampton game when they head to Cardiff on Saturday.
It's fourth against top in Saturday's clash at Stamford Bridge, with Manchester City looking for a fourth consecutive victory over Chelsea.
Two teams in contrasting form meet at the London Stadium on Saturday although just two places separate West Ham and Crystal Palace.
Burnley are without a win in six league games going into Saturday's home clash against a Brighton side unbeaten in three.
Arsenal will look to extend their unbeaten run in all competitions to 21 games when they face Huddersfield at the Emirates on Saturday.
Bournemouth returned to winning ways last time out but Saturday’s clash with Liverpool is likely to provide a serious test once again.
Manchester United will attempt to extend their unbeaten start to December when they welcome Fulham to Old Trafford.
Claudio Ranieri will look to get one over on his old club Leicester when they travel to take on his current side Fulham on Wednesday.
Everton will look to recover from their derby-day misery when they host Newcastle on Wednesday.
Wolves will be up against it in their bid to end a six-match winless run when they play host to Chelsea at Molineux on Wednesday.
Turf Moor will be the venue for the clash between second-from-bottom Burnley and second-from-top Liverpool on Wednesday night.
Arsenal will head to Manchester buoyed by their win over Tottenham in the derby as they seek to deepened the gloom at Old Trafford.
Kelvin Davis will take temporary charge of Southampton for their trip to Wembley to face Tottenham on Wednesday night.
Brighton and Crystal Palace will battle it out for bragging rights when they clash in the M23 derby on Tuesday.
Manchester City can extend their lead at the top to five points, if they can secure a victory at Watford on Tuesday night.
West Ham will look to build on their victory over Newcastle when they host an improving Cardiff on Tuesday.
Bournemouth will look to end a run of four straight defeats when they host Huddersfield on Tuesday evening.
Chelsea and Fulham meet for the west London bragging rights at high noon on Sunday in the Premier League.
Sunday sees the first north London derby of the season as Arsenal tackle Tottenham at the Emirates.
Manchester City will be eyeing a sixth straight Premier League win when they welcome out-of-sorts Bournemouth to the Etihad.
Newcastle will be looking for a fourth straight win when they welcome West Ham to St James' Park on Saturday.
Just two points and one place separate Leicester and Watford going into Saturday's clash between the pair at the King Power Stadium.
Anfield will host the 232nd Merseyside derby on Sunday afternoon, with Liverpool unbeaten in their last 17 meetings with Everton.
Southampton and Manchester United have both been hit by injury setbacks heading into Saturday evening's clash at St Mary's.
Huddersfield went unbeaten in November and will be hoping to extend that run into December when they host Brighton on Saturday.
Crystal Palace and Burnley appear in dire need of three points ahead of their meeting at Selhurst Park on Saturday.
Wolverhampton Wanderers will be looking to get back to winning ways when they travel to Cardiff City in Friday's Premier League game.
Villarreal could end Rangers' dream of qualifying for the Europa League group stages with a first-ever win in Scotland on Thursday.
Chelsea will be seeking to make it five out of five in the Europa League when Greek side PAOK visit Stamford Bridge on Thursday.
Celtic head to Rosenborg on Thursday knowing only a win is good enough in the race for the Europa League knockout stages.
Arsenal will look to secure top spot in Group E when they head to Ukrainian capital Kiev to face Vorskla Poltava in the Europa League.
Liverpool know a victory away at Paris Saint-Germain could see them progress from Champions League Group C.
Tottenham head into Wednesday's Champions League game against Inter Milan knowing they must win to maintain their qualification hopes.
Leicester City and Southampton do battle for a place in the EFL Cup quarter-finals at the King Power Stadium on Tuesday.
Manchester United could book their place in the last-16 of the Champions League on Tuesday when they play host to Young Boys.
Manchester City will be looking to secure their place in the last-16 of the Champions League when they travel to Lyon on Tuesday.
Newcastle United will be going for a third straight win when they make the trip to Turf Moor on Monday to take on Burnley.
Wolves go in search of their first win since October when they welcome Huddersfield Town to Molineux on Sunday.
Arsenal will be looking to break a run of draws when they make the trip to the Vitality Stadium on Sunday to take on Bournemouth.