West Ham welcome Manchester United to the London Stadium on Sunday hoping to extend their four-match unbeaten run in the league.
Wolves head to Crystal Palace on Sunday searching for their first win of the season and put an end to their poor form in the process.
Arsenal put their poor showing at Watford behind them in midweek and will now look to keep up their recent dominance of Aston Villa.
Chelsea have been boosted by the news that N'Golo Kante could return for Sunday's big clash with Liverpool at Stamford Bridge.
A win for Sheffield United at Goodison Park will take them above Everton in the table, while the hosts are eyeing a top-half spot.
Sean Dyche will become Burnley's fourth longest-serving manager when the Clarets face Norwich City on Saturday.
Newcastle and Brighton go in search of just their second wins of the season when they clash at St James' Park on Saturday evening.
Leicester City will look to bounce back from their defeat to Manchester United when they welcome Tottenham to King Power Stadium.
Manchester City will be eager to prove a point when they host Watford in the Premier League on Saturday.
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Southampton will look to extend their unbeaten run to five matches when they take on Bournemouth on Friday night in the Premier League.
Manchester United start their quest for back-to-back Europa League titles on Thursday when they play host to Astana of Kazakhstan.
Wolves will seek to get their season back on track when they play host to Portuguese side Braga in the Europa League on Thursday.
Arsenal face a tricky start to their quest to go one better in this year's Europa League when they travel to Eintracht Frankfurt.
Manchester City will face familiar opponents when they get their Champions League campaign underway against Shakhtar Donetsk.
Tottenham's opening match of this season's Champions League will see them travel to Greece to take on Olympiakos on Wednesday.
West Ham will go third in the Premier League table if they win at Aston Villa on Monday.
Tottenham will be looking to get back to winning ways when they host Crystal Palace in the Premier League on Saturday afternoon.
Watford will look to avoid equalling their record of five consecutive top-flight defeats when they welcome Arsenal to Vicarage Road.
Norwich welcome Premier League champions Manchester City to Carrow Road this weekend hoping to end a run of defeats.
Romain Saiss is expected to be handed a start for Wolves when they host Chelsea on Saturday afternoon.
Bournemouth will look to extend their unbeaten home record against Everton when they meet in the Premier League on Sunday afternoon.
Liverpool will look to maintain their 100 per cent record on Saturday when the Premier League leaders play host to Newcastle.
Ole Gunnar Solskjaer says Paul Pogba is expected to miss Saturday's big clash with Leicester City at Old Trafford.
Sheffield United face Southampton on Saturday hoping the momentum from their comeback at Chelsea has not been lost.
Brighton and Burnley will bid to put their respective thrashings by Man City and Liverpool behind them at the Amex Stadium on Saturday.